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Tchem
DNM1L
Dynamin-1-like protein

Protein Summary
Description
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266481
  • ENSP00000266481
  • ENSG00000087470
  • ENST00000381000
  • ENSP00000370388
  • ENST00000414834
  • ENSP00000404160
  • ENST00000452533
  • ENSP00000415131
  • ENST00000547312
  • ENSP00000448610
  • ENST00000549701
  • ENSP00000450399
  • ENST00000553257
  • ENSP00000449089

Symbol
  • DLP1
  • DRP1
  • DLP1
  • DRP1
  • DVLP
  • EMPF
  • OPA5
  • EMPF1
  • DYMPLE
  • HDYNIV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.98
protein domain
0.97
transcription factor perturbation
0.97
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.46   (req: < 5)
Gene RIFs: 285   (req: <= 3)
Antibodies: 580   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.46   (req: >= 5)
Gene RIFs: 285   (req: > 3)
Antibodies: 580   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0