Protein Summary
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
- ENST00000265109
- ENSP00000265109
- ENSG00000039560
- ENST00000428746
- ENSP00000388725
- ENST00000503673
- ENSP00000422942
- ENST00000506376
- ENSP00000423854
- ENST00000512629
- ENSP00000422377
- ENST00000515799
- ENSP00000427123
- KIAA1334
- NORPEG
- RAI13
- NORPEG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.93 | ||
PubMedID | 0.86 | ||
transcription factor binding site profile | 0.85 | ||
histone modification site profile | 0.83 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.75 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 69 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.75 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 69 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0