Tbio MSH3 DNA mismatch repair protein Msh3

Protein Summary

Description

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• P20585
• A1L480
• A1L482
• A6NMM6
• Q6PJT5
• Q86UQ6
• Q92867
• hMSH3

Gene Name

• MSH3

Ensembl ID

• ENST00000265081
• ENSP00000265081
• ENSG00000113318

Symbol

• DUC1
• DUG
• DUP
• FAP4
• MRP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
molecular function	1
kinase perturbation	0.93
protein domain	0.92
histone modification site profile	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Mismatch Repair Protein Msh3

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Mismatch Repair Protein Msh3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.04   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.04   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0