Tchem NPR3 Atrial natriuretic peptide receptor 3

Protein Summary

Description

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P17342
• A2RRD1
• B4DT84
• E7EPG9

Gene Name

• NPR3

Ensembl ID

• ENST00000265074
• ENSP00000265074
• ENSG00000113389
• ENST00000326958
• ENSP00000318340
• ENST00000415167
• ENSP00000398028

Symbol

• ANPRC
• C5orf23
• NPRC
• NPRC
• ANP-C
• ANPRC
• NPR-C
• ANPR-C
• GUCY2B
• C5orf23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
gene perturbation	0.84
transcription factor perturbation	0.8
transcription factor binding site profile	0.79
small molecule perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 552.41   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 397   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 552.41   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0