Tbio GRPEL1 GrpE protein homolog 1, mitochondrial

Protein Summary

Description

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562).

Uniprot Accession IDs

• Q9HAV7
• B2R783
• Q549M6

Gene Name

• GRPEL1

Ensembl ID

• ENST00000264954
• ENSP00000264954
• ENSG00000109519

Symbol

• GREPEL1
• GrpE
• HMGE
• mt-GrpE#1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.87
histone modification site profile	0.87
interacting protein	0.84
transcription factor binding site profile	0.77

Protein Classes

PANTHER Classes

Protein / Chaperone / Grpe Protein Homolog 1, Mitochondrial

DTO Classes

Protein / Chaperone / Grpe Protein Homolog 1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.81   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.81   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0