Tbio SCARB2 Lysosome membrane protein 2

Protein Summary

Description

Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. (Microbial infection) Acts as a receptor for enterovirus 71. The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q14108
• B4DKD8
• E7EM68
• Q53Y63

Gene Name

• SCARB2

Ensembl ID

• ENST00000264896
• ENSP00000264896
• ENSG00000138760
• ENST00000452464
• ENSP00000399154

Symbol

• CD36L2
• LIMP2
• LIMPII
• AMRF
• EPM4
• LGP85
• CD36L2
• HLGP85
• LIMP-2
• LIMPII
• SR-BII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	1
virus perturbation	1
kinase perturbation	0.99
interacting protein	0.93

Protein Classes

PANTHER Classes

Protein / Receptor / Lysosome Membrane Protein 2

DTO Classes

Protein / Receptor / Lysosome Membrane Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1676.19   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 368   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1676.19   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0