You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TYK2
Non-receptor tyrosine-protein kinase TYK2

Protein Summary
Description
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264818
  • ENSP00000264818
  • ENSG00000105397
  • ENST00000525621
  • ENSP00000431885

Symbol
  • JTK1
  • IMD35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
histone modification site profile
0.91
hub protein
0.85
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.71   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 665   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.71   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 665   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 417
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8