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Tchem
STAT3
Signal transducer and activator of transcription 3

Protein Summary
Description
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264657
  • ENSP00000264657
  • ENSG00000168610
  • ENST00000404395
  • ENSP00000384943
  • ENST00000585517
  • ENSP00000467000
  • ENST00000588969
  • ENSP00000467985

Symbol
  • APRF
  • APRF
  • HIES
  • ADMIO
  • ADMIO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
1
hub protein
1


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11004.99   (req: < 5)
Gene RIFs: 3201   (req: <= 3)
Antibodies: 2254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11004.99   (req: >= 5)
Gene RIFs: 3201   (req: > 3)
Antibodies: 2254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 91
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 163
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2