Tbio KCNK6 Potassium channel subfamily K member 6

Protein Summary

Description

Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y257
• Q9HB47

Gene Name

• KCNK6

Ensembl ID

• ENST00000263372
• ENSP00000263372
• ENSG00000099337

Symbol

• TOSS
• TWIK2
• TOSS
• KCNK8
• TWIK2
• K2p6.1
• TWIK-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
virus perturbation	0.88
protein domain	0.73
PubMedID	0.6
histone modification site profile	0.54

Protein Classes

DTO Classes

Protein / Ion Channel / Two Pore Domain Potassium Channel Family / Potassium Channel Subfamily K Member 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.11   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.11   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0