Protein Summary
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
- ENST00000263334
- ENSP00000263334
- ENSG00000125618
- ENST00000263335
- ENSP00000263335
- ENST00000348715
- ENSP00000314750
- ENST00000397647
- ENSP00000380768
- ENST00000429538
- ENSP00000395498
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
co-expressed gene | 0.97 | ||
molecular function | 0.88 | ||
disease perturbation | 0.87 | ||
biological term | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 946.62 (req: < 5)
Gene RIFs: 207 (req: <= 3)
Antibodies: 780 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 946.62 (req: >= 5)
Gene RIFs: 207 (req: > 3)
Antibodies: 780 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 42
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 57
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3