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Tbio
CBFA2T2
Protein CBFA2T2

Protein Summary
Description
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342704
  • ENSP00000345810
  • ENSG00000078699
  • ENST00000344201
  • ENSP00000341865
  • ENST00000346541
  • ENSP00000262653
  • ENST00000359606
  • ENSP00000352622
  • ENST00000375279
  • ENSP00000364428
  • ENST00000397800
  • ENSP00000380902
  • ENST00000492345
  • ENSP00000433270

Symbol
  • EHT
  • MTGR1
  • EHT
  • p85
  • MTGR1
  • ZMYND3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.88
transcription factor
0.88
cell type or tissue
0.83
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.93   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.93   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0