Tdark CEP76 Centrosomal protein of 76 kDa

Protein Summary

Description

Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q8TAP6
• B0YJB2
• B4DXG5
• B4DZW1
• Q658N5
• Q9H9U7
• Cep76

Gene Name

• CEP76

Ensembl ID

• ENST00000262127
• ENSP00000262127
• ENSG00000101624
• ENST00000423709
• ENSP00000403074

Symbol

• C18orf9
• C18orf9
• HsT1705

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.94
tissue sample	0.71
kinase perturbation	0.66
cell line	0.63
transcription factor binding site profile	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.5   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.5   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0