Tbio VSX2 Visual system homeobox 2

Protein Summary

Description

Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity). This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P58304
• A1A4X6

Gene Name

• VSX2

Ensembl ID

• ENST00000261980
• ENSP00000261980
• ENSG00000119614

Symbol

• CHX10
• HOX10
• RET1
• CHX10
• HOX10
• MCOP2
• MCOPCB3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
biological process	0.64
hub protein	0.63
PubMedID	0.56
microRNA	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.78   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.78   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0