Tbio AAGAB Alpha- and gamma-adaptin-binding protein p34

Protein Summary

Description

May be involved in endocytic recycling of growth factor receptors such as EGFR. The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q6PD74
• B4DG44
• Q6FI86
• Q7Z5X9
• Q9H0P1
• Q9HAK0

Gene Name

• AAGAB

Ensembl ID

• ENST00000261880
• ENSP00000261880
• ENSG00000103591
• ENST00000542650
• ENSP00000440735
• ENST00000561452
• ENSP00000453263

Symbol

• p34
• KPPP1
• PPKP1
• PPKP1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
histone modification site profile	0.87
disease perturbation	0.74
transcription factor perturbation	0.74
cell type or tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.74   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.74   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0