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Tclin
PDGFRB
Platelet-derived growth factor receptor beta

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261799
  • ENSP00000261799
  • ENSG00000113721

Symbol
  • PDGFR
  • PDGFR1
  • IMF1
  • KOGS
  • IBGC4
  • JTK12
  • PDGFR
  • PENTT
  • CD140B
  • PDGFR1
  • PDGFR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
molecular function
1
protein domain
1
hub protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1466.63   (req: < 5)
Gene RIFs: 338   (req: <= 3)
Antibodies: 1897   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1466.63   (req: >= 5)
Gene RIFs: 338   (req: > 3)
Antibodies: 1897   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 424
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13