Tbio MPP5 MAGUK p55 subfamily member 5

Protein Summary

Description

May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8N3R9
• A1L380
• Q7Z631
• Q86T98
• Q8N7I5
• Q9H9Q0

Gene Name

• MPP5

Ensembl ID

• ENST00000261681
• ENSP00000261681
• ENSG00000072415
• ENST00000555925
• ENSP00000451488

Symbol

• PALS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.93
histone modification site profile	0.86
cellular component	0.79
microRNA	0.78

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Maguk P55 Subfamily Member 5

Protein / Cell Junction Protein / Maguk P55 Subfamily Member 5

DTO Classes

Protein / Enzyme / Transferase / Maguk P55 Subfamily Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.57   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 305   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.57   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0