Tbio XYLT1 Xylosyltransferase 1

Protein Summary

Description

Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q86Y38
• Q9H1B6

Gene Name

• XYLT1

Ensembl ID

• ENST00000261381
• ENSP00000261381
• ENSG00000103489
• ENST00000644858
• ENSP00000495604
• ENSG00000285395

Symbol

• XT1
• XT1
• XTI
• XT-I
• DBQD2
• XYLTI
• PXYLT1
• xylT-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.65
disease	0.63
interacting protein	0.61
tissue sample	0.61
trait	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.59   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.59   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0