Tbio SULF1 Extracellular sulfatase Sulf-1

Protein Summary

Description

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q8IWU6
• Q86YV8
• Q8NCA2
• Q9UPS5
• hSulf-1

Gene Name

• SULF1

Ensembl ID

• ENST00000260128
• ENSP00000260128
• ENSG00000137573
• ENST00000402687
• ENSP00000385704
• ENST00000419716
• ENSP00000390315
• ENST00000458141
• ENSP00000403040

Symbol

• KIAA1077
• SULF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
transcription factor perturbation	0.94
gene perturbation	0.88
biological process	0.85
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Hydrolase / Extracellular Sulfatase Sulf-1

DTO Classes

Protein / Enzyme / Hydrolase / Extracellular Sulfatase Sulf-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.68   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.68   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0