Protein Summary
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
- ENST00000259456
- ENSP00000259456
- ENSG00000136929
- ENST00000616898
- ENSP00000480020
- EDAG
- NDR
- NDR
- EDAG
- CT155
- EDAG-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 1 | ||
virus perturbation | 0.97 | ||
cell type or tissue | 0.7 | ||
tissue | 0.47 | ||
cell line | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.7 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.7 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0