Tbio PRPH Peripherin

Protein Summary

Description

Class-III neuronal intermediate filament protein. This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P41219
• Q8N577

Gene Name

• PRPH

Ensembl ID

• ENST00000257860
• ENSP00000257860
• ENSG00000135406

Symbol

• NEF4
• PRPH1
• NEF4
• PRPH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
virus perturbation	0.83
gene perturbation	0.81
cellular component	0.79
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 413   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0