Protein Summary
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
- ENST00000256906
- ENSP00000256906
- ENSG00000134489
- ENST00000426880
- ENSP00000402526
- GPCR105
- H4
- H4R
- BG26
- HH4R
- AXOR35
- GPRv53
- GPCR105
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.91 | ||
biological process | 0.78 | ||
gene perturbation | 0.78 | ||
tissue sample | 0.74 | ||
biological term | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 378.92 (req: < 5)
Gene RIFs: 89 (req: <= 3)
Antibodies: 276 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 378.92 (req: >= 5)
Gene RIFs: 89 (req: > 3)
Antibodies: 276 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 568
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3