Tbio SYNJ2BP Synaptojanin-2-binding protein

Protein Summary

Description

Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.

Uniprot Accession IDs

• P57105
• Q49SH3
• Q96IA4

Gene Name

• SYNJ2BP

Ensembl ID

• ENST00000256366
• ENSP00000256366
• ENSG00000213463

Symbol

• OMP25
• ARIP2
• OMP25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
interacting protein	0.95
kinase perturbation	0.93
transcription factor perturbation	0.91
histone modification site profile	0.81

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Synaptojanin-2-binding Protein

DTO Classes

Protein / Receptor / Synaptojanin-2-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.32   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.32   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0