Tbio ALDH3B2 Aldehyde dehydrogenase family 3 member B2

Protein Summary

Description

Oxidizes medium and long chain aldehydes into non-toxic fatty acids. This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P48448
• Q53Y98
• Q8NAL5
• Q96IB2

Gene Name

• ALDH3B2

Ensembl ID

• ENST00000349015
• ENSP00000255084
• ENSG00000132746
• ENST00000530069
• ENSP00000431595

Symbol

• ALDH8
• ALDH8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
cell type or tissue	0.68
pathway	0.67
cell line	0.62
microRNA	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.62   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.62   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0