Tdark WDR7 WD repeat-containing protein 7

Protein Summary

Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y4E6
• A7E2C8
• Q86UX5
• Q86VP2
• Q96PS7

Gene Name

• WDR7

Ensembl ID

• ENST00000254442
• ENSP00000254442
• ENSG00000091157
• ENST00000357574
• ENSP00000350187

Symbol

• KIAA0541
• TRAG
• TRAG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
histone modification site profile	0.84
disease perturbation	0.83
virus perturbation	0.79
transcription factor	0.76

Protein Classes

DTO Classes

Wd Repeat-containing Protein 74 / F-box/wd Repeat-containing Protein 7 / Wd Repeat-containing Protein 78

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.54   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.54   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0