Tbio LAMA5 Laminin subunit alpha-5

Protein Summary

Description

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• O15230
• Q5U4N9
• Q8TDF8
• Q8WZA7
• Q9H1P1

Gene Name

• LAMA5

Ensembl ID

• ENST00000252999
• ENSP00000252999
• ENSG00000130702

Symbol

• KIAA0533
• KIAA1907

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.9
transcription factor perturbation	0.88
disease perturbation	0.87
transcription factor binding site profile	0.76

Protein Classes

PANTHER Classes

Protein / Receptor / Laminin Subunit Alpha-5

Protein / Extracellular Matrix Protein / Extracellular Matrix Linker Protein / Laminin Subunit Alpha-5

Protein / ... / Protease Inhibitor / Laminin Subunit Alpha-5

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Laminin Subunit Alpha-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.2   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.2   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0