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Tdark
ARFGEF3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

Protein Summary
Description
Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251691
  • ENSP00000251691
  • ENSG00000112379

Symbol
  • BIG3
  • C6orf92
  • KIAA1244
  • BIG3
  • A7322
  • C6orf92
  • PPP1R33
  • KIAA1244
  • dJ171N11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
virus perturbation
0.83
gene perturbation
0.76
histone modification site profile
0.76
PubMedID
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0