CIAO3
Cytosolic iron-sulfur assembly component 3
Protein Summary
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
- ENST00000251588
- ENSP00000251588
- ENSG00000103245
- ENST00000540986
- ENSP00000444008
- ENST00000568545
- ENSP00000457058
- NARFL
- PRN
- PRN
- HPRN
- IOP1
- NAR1
- LET1L
- NARFL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.83 | ||
transcription factor | 0.79 | ||
transcription factor binding site profile | 0.77 | ||
tissue sample | 0.7 | ||
cell line | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.18 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 165 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.18 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 165 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0