You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NALCN
Sodium leak channel non-selective protein

Protein Summary
Description
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity). This gene encodes a voltage-independent, nonsel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251127
  • ENSP00000251127
  • ENSG00000102452
  • ENST00000376200
  • ENSP00000365373

Symbol
  • VGCNL1
  • IHPRF
  • INNFD
  • CanIon
  • IHPRF1
  • VGCNL1
  • CLIFAHDD
  • bA430M15.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
virus perturbation
0.76
trait
0.75
histone modification site profile
0.64
gene perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.49   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.49   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1