Tbio DAZL Deleted in azoospermia-like

Protein Summary

Description

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q92904
• O15396
• Q5HYB4
• Q92909

Gene Name

• DAZL

Ensembl ID

• ENST00000250863
• ENSP00000250863
• ENSG00000092345
• ENST00000399444
• ENSP00000382373

Symbol

• DAZH
• DAZL1
• DAZLA
• SPGYLA
• DAZH
• DAZL1
• DAZLA
• SPGYLA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.76
co-expressed gene	0.65
biological process	0.62
molecular function	0.6
cellular component	0.57

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Deleted In Azoospermia-like

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Deleted In Azoospermia-like

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.38   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.38   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0