Tbio SGSM3 Small G protein signaling modulator 3

Protein Summary

Description

May play a cooperative role in NF2-mediated growth suppression of cells.

Uniprot Accession IDs

• Q96HU1
• B0QY79
• Q7Z709
• Q9NT69

Gene Name

• SGSM3

Ensembl ID

• ENST00000248929
• ENSP00000248929
• ENSG00000100359

Symbol

• MAP
• RABGAPLP
• RUTBC3
• MAP
• CIP85
• RUSC3
• RUTBC3
• RABGAP5
• RabGAP-5
• rabGAPLP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.62
histone modification site profile	0.62
tissue sample	0.62
cell line	0.59
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Hydrolase / Small G Protein Signaling Modulator 3

Protein / Enzyme Modulator / G-protein Modulator / Small G Protein Signaling Modulator 3

Protein / ... / Cysteine Protease / Small G Protein Signaling Modulator 3

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Small G Protein Signaling Modulator 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.19   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.19   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0