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Tbio
STYXL1
Serine/threonine/tyrosine-interacting-like protein 1

Protein Summary
Description
Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248600
  • ENSP00000248600
  • ENSG00000127952
  • ENST00000340062
  • ENSP00000343383
  • ENST00000359697
  • ENSP00000352726
  • ENST00000360591
  • ENSP00000353798
  • ENST00000431581
  • ENSP00000392221

Symbol
  • DUSP24
  • MKSTYX
  • DUSP24
  • MKSTYX
  • MK-STYX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
cell type or tissue
0.78
protein domain
0.73
virus perturbation
0.72
cellular component
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0