Tbio SRSF6 Serine/arginine-rich splicing factor 6

Protein Summary

Description

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q13247
• B7Z6J3
• E1P5W6
• Q13244
• Q13245
• Q96J06
• Q9UJB8
• Q9Y3N7

Gene Name

• SRSF6

Ensembl ID

• ENST00000244020
• ENSP00000244020
• ENSG00000124193
• ENST00000483871
• ENSP00000433544

Symbol

• SFRS6
• SRP55
• B52
• SFRS6
• SRP55
• HEL-S-91

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
virus perturbation	0.98
disease perturbation	0.93
transcription factor perturbation	0.88
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.73   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.73   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0