Tbio SLC25A2 Mitochondrial ornithine transporter 2

Protein Summary

Description

Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q9BXI2
• Q496C1
• Q6XUI0
• Q8NFZ2

Gene Name

• SLC25A2

Ensembl ID

• ENST00000239451
• ENSP00000239451
• ENSG00000120329

Symbol

• ORNT2
• ORC2
• ORNT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.66
cellular component	0.64
tissue sample	0.53
metabolite	0.45
cell line	0.41

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc25 Family Of Mitochondrial Transporters / Mitochondrial Amino Acid Transporter Subfamily / Mitochondrial Ornithine Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.97   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.97   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0