Tbio BCL9 B-cell CLL/lymphoma 9 protein

Protein Summary

Description

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00512
• Q5T489
• B-cell lymphoma 9 protein

Gene Name

• BCL9

Ensembl ID

• ENST00000234739
• ENSP00000234739
• ENSG00000116128

Symbol

• LGS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.71
small molecule perturbation	0.69
transcription factor	0.64
microRNA	0.63
cell line	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.6   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.6   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0