Tbio DAZAP1 DAZ-associated protein 1

Protein Summary

Description

RNA-binding protein, which may be required during spermatogenesis. In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96EP5
• Q96MJ3
• Q9NRR9

Gene Name

• DAZAP1

Ensembl ID

• ENST00000233078
• ENSP00000233078
• ENSG00000071626
• ENST00000336761
• ENSP00000337132

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor binding site profile	0.88
kinase perturbation	0.71
virus perturbation	0.59
transcription factor	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.76   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.76   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0