Tbio RANGRF Ran guanine nucleotide release factor

Protein Summary

Description

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q9HD47
• D3DTR6
• Q68DI3
• Q9BR68
• Q9HD48
• Q9NRU9
• Q9P001
• Q9P0P2
• RanGNRF

Gene Name

• RANGRF

Ensembl ID

• ENST00000226105
• ENSP00000226105
• ENSG00000108961
• ENST00000407006
• ENSP00000383940
• ENST00000439238
• ENSP00000413190
• ENST00000580434
• ENSP00000462310

Symbol

• MOG1
• RANGNRF
• MOG1
• HSPC165
• HSPC236
• RANGNRF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
disease perturbation	0.74
kinase perturbation	0.66
tissue sample	0.65
gene perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.28   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.28   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0