Tbio CD79A B-cell antigen receptor complex-associated protein alpha chain

Protein Summary

Description

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11912
• A0N775
• Q53FB8

Gene Name

• CD79A

Ensembl ID

• ENST00000221972
• ENSP00000221972
• ENSG00000105369
• ENST00000444740
• ENSP00000400605

Symbol

• IGA
• MB1
• IGA
• MB-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
PubMedID	0.62
cellular component	0.6
kinase	0.6
tissue	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / B-cell Antigen Receptor Complex-associated Protein Alpha Chain

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / B-cell Antigen Receptor Complex-associated Protein Alpha Chain

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / B-cell Antigen Receptor Complex-associated Protein Alpha Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 904.94   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 2045   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 904.94   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 2045   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0