Tbio EBI3 Interleukin-27 subunit beta

Protein Summary

Description

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q14213
• A0N0N2
• O75269
• IL-27 subunit beta

Gene Name

• EBI3

Ensembl ID

• ENST00000221847
• ENSP00000221847
• ENSG00000105246

Symbol

• IL27B
• IL27B
• IL35B
• IL-27B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.73
kinase perturbation	0.66
co-expressed gene	0.61
tissue sample	0.59
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-27 Subunit Beta

Protein / Defense/immunity Protein / Interleukin-27 Subunit Beta

DTO Classes

Protein / Signaling / Cytokine / Interleukin-27 Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 820   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 820   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0