Tbio NEFM Neurofilament medium polypeptide

Protein Summary

Description

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P07197
• B4DGN2
• E9PBF7
• Q4QRK6
• NF-M

Gene Name

• NEFM

Ensembl ID

• ENST00000221166
• ENSP00000221166
• ENSG00000104722
• ENST00000433454
• ENSP00000412295

Symbol

• NEF3
• NFM
• NFM
• NEF3
• NF-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
PubMedID	0.77
protein domain	0.73
cell type or tissue	0.68
chemical	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 480.11   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 638   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 480.11   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0