Tbio CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Protein Summary

Description

Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• O14735
• B4DUV0
• H3BTV1
• Q6FGU1
• Q6ZN70

Gene Name

• CDIPT

Ensembl ID

• ENST00000219789
• ENSP00000219789
• ENSG00000103502
• ENST00000566113
• ENSP00000457340
• ENST00000569956
• ENSP00000457339
• ENST00000570016
• ENSP00000454453

Symbol

• PIS
• PIS1
• PIS
• PIS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
kinase perturbation	0.95
metabolite	0.83
cellular component	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.6   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.6   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0