DHODH
Dihydroorotate dehydrogenase (quinone), mitochondrial
Protein Summary
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
- ENST00000219240
- ENSP00000219240
- ENSG00000102967
- URA1
- POADS
- DHOdehase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 0.91 | ||
disease perturbation | 0.87 | ||
histone modification site profile | 0.85 | ||
biological process | 0.84 | ||
cellular component | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 591.6 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 591.6 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 616
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2