BCORL1
BCL-6 corepressor-like protein 1
Protein Summary
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
- ENST00000218147
- ENSP00000218147
- ENSG00000085185
- ENST00000540052
- ENSP00000437775
- BCoR-L1
- CXorf10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.69 | ||
small molecule perturbation | 0.69 | ||
kinase perturbation | 0.6 | ||
disease perturbation | 0.56 | ||
microRNA | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.38 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 77 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.38 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 77 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0