Tbio SALL4 Sal-like protein 4

Protein Summary

Description

Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9UJQ4
• A2A2D8
• Q540H3
• Q6Y8G6

Gene Name

• SALL4

Ensembl ID

• ENST00000217086
• ENSP00000217086
• ENSG00000101115
• ENST00000395997
• ENSP00000379319

Symbol

• ZNF797
• DRRS
• HSAL4
• ZNF797

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.76
PubMedID	0.74
biological term	0.72
transcription factor binding site profile	0.69
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / ... / C2h2 Zinc Finger Transcription Factor / Sal-like Protein 4

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Sal-like Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.71   (req: < 5)

Gene RIFs: 170   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.71   (req: >= 5)

Gene RIFs: 170   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0