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Tchem
XBP1
X-box-binding protein 1

Protein Summary
Description
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216037
  • ENSP00000216037
  • ENSG00000100219
  • ENST00000344347
  • ENSP00000343155
  • ENST00000611155
  • ENSP00000481170

Symbol
  • TREB5
  • XBP2
  • XBP2
  • TREB5
  • XBP-1
  • TREB-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.99
small molecule perturbation
0.92
virus perturbation
0.92
transcription factor binding site profile
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1398.13   (req: < 5)
Gene RIFs: 276   (req: <= 3)
Antibodies: 662   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1398.13   (req: >= 5)
Gene RIFs: 276   (req: > 3)
Antibodies: 662   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 97
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0