Protein Summary
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- ENST00000210633
- ENSP00000210633
- ENSG00000095539
- ENST00000370250
- ENSP00000359270
- ENST00000517724
- ENSP00000430175
- ENST00000521006
- ENSP00000430881
- KIAA1619
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
cell line | 0.61 | ||
cell type or tissue | 0.6 | ||
transcription factor | 0.6 | ||
small molecule perturbation | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.9 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 53 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.9 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 53 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0