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Tbio
DLD
Dihydrolipoyl dehydrogenase, mitochondrial

Protein Summary
Description
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205402
  • ENSP00000205402
  • ENSG00000091140
  • ENST00000417551
  • ENSP00000390667
  • ENST00000437604
  • ENSP00000387542

Symbol
  • GCSL
  • LAD
  • PHE3
  • E3
  • LAD
  • DLDD
  • DLDH
  • GCSL
  • PHE3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
virus perturbation
0.94
disease perturbation
0.93
protein domain
0.92
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.14   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.14   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0