Protein Summary
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
- ENST00000011292
- ENSP00000011292
- ENSG00000091704
- CPA
- CPA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug | 0.68 | ||
hub protein | 0.58 | ||
tissue sample | 0.58 | ||
disease perturbation | 0.56 | ||
molecular function | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 220.67 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 394 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 220.67 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 394 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0