| Tbio | Bis(5'-adenosyl)-triphosphatase ENPP4 |
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 5.4e-14 |
| psoriasis | 6694 | 3.0e-07 |
| medulloblastoma, large-cell | 6241 | 1.2e-05 |
| glioblastoma multiforme | 142 | 2.2e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-04 |
| lung cancer | 4740 | 1.4e-04 |
| group 3 medulloblastoma | 4104 | 1.0e-03 |
| ovarian cancer | 8520 | 1.2e-03 |
| primitive neuroectodermal tumor | 3035 | 2.3e-03 |
| Atopic dermatitis | 952 | 2.4e-03 |
| hereditary spastic paraplegia | 318 | 5.5e-03 |
| adult high grade glioma | 3801 | 5.6e-03 |
| Down syndrome | 499 | 6.4e-03 |
| Pick disease | 1894 | 8.6e-03 |
| nasopharyngeal carcinoma | 1058 | 1.0e-02 |
| progressive supranuclear palsy | 676 | 1.2e-02 |
| astrocytoma | 1146 | 1.5e-02 |
| osteosarcoma | 7950 | 2.3e-02 |
| spina bifida | 1074 | 2.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.500 | 5.6e-03 |
| astrocytoma | -1.600 | 1.5e-02 |
| Atopic dermatitis | -1.100 | 2.4e-03 |
| atypical teratoid / rhabdoid tumor | -1.900 | 1.1e-04 |
| Down syndrome | 1.100 | 6.4e-03 |
| glioblastoma multiforme | -1.100 | 2.2e-05 |
| group 3 medulloblastoma | -2.300 | 1.0e-03 |
| hereditary spastic paraplegia | -1.166 | 5.5e-03 |
| lung cancer | -1.700 | 1.4e-04 |
| medulloblastoma, large-cell | -2.100 | 1.2e-05 |
| nasopharyngeal carcinoma | -1.300 | 1.0e-02 |
| non-small cell lung cancer | -1.847 | 5.4e-14 |
| osteosarcoma | -1.442 | 2.3e-02 |
| ovarian cancer | 1.700 | 1.2e-03 |
| Pick disease | -1.400 | 8.6e-03 |
| primitive neuroectodermal tumor | -1.300 | 2.3e-03 |
| progressive supranuclear palsy | -1.600 | 1.2e-02 |
| psoriasis | -1.400 | 3.0e-07 |
| spina bifida | -1.196 | 2.8e-02 |
MKLLVILLFSGLITGFRSDSSSSLPPKLLLVSFDGFRADYLKNYEFPHLQNFIKEGVLVEHVKNVFITKT 1 - 70 FPNHYSIVTGLYEESHGIVANSMYDAVTKKHFSDSNDKDPFWWNEAVPIWVTNQLQENRSSAAAMWPGTD 71 - 140 VPIHDTISSYFMNYNSSVSFEERLNNITMWLNNSNPPVTFATLYWEEPDASGHKYGPEDKENMSRVLKKI 141 - 210 DDLIGDLVQRLKMLGLWENLNVIITSDHGMTQCSQDRLINLDSCIDHSYYTLIDLSPVAAILPKINRTEV 211 - 280 YNKLKNCSPHMNVYLKEDIPNRFYYQHNDRIQPIILVADEGWTIVLNESSQKLGDHGYDNSLPSMHPFLA 281 - 350 AHGPAFHKGYKHSTINIVDIYPMMCHILGLKPHPNNGTFGHTKCLLVDQWCINLPEAIAIVIGSLLVLTM 351 - 420 LTCLIIIMQNRLSVPRPFSRLQLQEDDDDPLIG 421 - 453 //
