Tbio ENAH Protein enabled homolog

Protein Summary

Description

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q8N8S7
• D0PQI2
• Q502W5
• Q5T5M7
• Q5VTQ9
• Q5VTR0
• Q9NVF3
• Q9UFB8

Gene Name

• ENAH

Ensembl ID

• ENST00000366843
• ENSP00000355808
• ENSG00000154380
• ENST00000366844
• ENSP00000355809

Symbol

• MENA
• ENA
• MENA
• NDPP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
ligand (protein) perturbation	0.96
virus perturbation	0.95
kinase perturbation	0.93
disease perturbation	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.74   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.74   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0