Tbio ELF4 ETS-related transcription factor Elf-4

Protein Summary

Description

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q99607
• D3DTG1
• O60435

Gene Name

• ELF4

Ensembl ID

• ENST00000308167
• ENSP00000311280
• ENSG00000102034
• ENST00000335997
• ENSP00000338608

Symbol

• ELFR
• MEF
• MEF
• ELFR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
transcription factor perturbation	0.88
molecular function	0.79
virus perturbation	0.79
PubMedID	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ets-related Transcription Factor Elf-4

Protein / Signaling Molecule / Ets-related Transcription Factor Elf-4

Protein / Nucleic Acid Binding / Ets-related Transcription Factor Elf-4

Protein / ... / Winged Helix/forkhead Transcription Factor / Ets-related Transcription Factor Elf-4

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Ets-related Transcription Factor Elf-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.91   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.91   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0